MultiFocus Research

Chronic psychological stress impairs recovery of muscular function and somatic sensations over a 96-hour period

https://www.ncbi.nlm.nih.gov/pubmed/24343323

Key Takeaways

In all analyses, higher stress was associated with worse recovery. Stress, whether assessed as life event stress or perceived stress, moderated the recovery trajectories of muscular function and somatic sensations in a 96-hour period after strenuous resistance exercise.


 A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/

Key Takeaways

The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life.


 KSM-66 Ashwagandha Shows Anti-Aging Effect on Chromosomes in New Study

http://www.nutritionaloutlook.com/herbs-botanicals/ksm-66-ashwagandha-shows-anti-aging-effect-chromosomes-new-study

Key Takeaways

This is the first published study to use a standardized, branded ashwagandha extract that shows an anti-aging effect with a telomerase promotion effect in the human cell line.


Holy Basil: An Overview of the Research and Clinical Indications

http://www.gaiaherbs.com/uploads/1596_HPR_HolyBasil_ResearchPaper-1371567034.pdf

Key Takeaways

The overall botanical medicine benefit profile for Holy Basil makes it a viable botanical agent for promoting improved resilience to stress, recovery from chronic stress and avoidance of acute and chronic stress-induced physiologic changes.


Mitochondrial Protection and Anti-aging Activity of Astragalus Polysaccharides and Their Potential Mechanism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291990/

Key Takeaways

According to this research, Astragalus polysaccharides protect mitochondria by scavenging reactive oxygen species (ROS), inhibiting mitochondrial PT and increasing the activities of antioxidases. Therefore, APS has the effect of promoting health


Study: Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/#B21-pharmaceuticals-03-00188

Key Takeaways

It was discovered that the stress—protective activity of adaptogens was associated with regulation of homeostasis via several mechanisms of action, which was linked with the hypothalamic-pituitary-adrenal axis and the regulation of key mediators of stress response, such as molecular chaperons (e.g., HSP70), stress-activated c-Jun N-terminal protein kinase 1 (JNK1), Forkhead box O (FOXO) transcription factor DAF-16, cortisol and nitric oxide.


A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue

http://www.lifeextension.com/magazine/2011/9/Reducing-the-Risks-of-High-Cortisol/Page-01

Key Takeaways

Subjects taking the rhodiola extract had significantly lower cortisol responses to chronic stress than did the placebo recipients—and as a result they had lower scores on scales of burnout and improved performance on cognitive testing.


Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression

https://www.ncbi.nlm.nih.gov/pubmed/17990195

Key Takeaways

For individuals in groups A and B, overall depression, together with insomnia, emotional instability and somatization, but not self-esteem, improved significantly following medication, whilst the placebo group did not show such improvements. No serious side-effects were reported in any of the groups A-C. It is concluded that the standardized extract SHR-5 shows anti-depressive potency in patients with mild to moderate depression when administered in dosages of either 340 or 680 mg/day over a 6-week period.

DAV Research

 

The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092581/

Key Takeaways

The Velvet Antler powder, dehydrated by lyophilization, might preserve more bioactive components.

Research suggests DAV potentially plays a role in suppressing pro-inflammatory cytokines – proteins created by the body in response to damage and injury.

Chondroitin sulfate, a potent anti-inflammatory agent, is the most prominent glycosaminoglycans in velvet antler tissue. This component has been used by arthritis patients with excellent results.


Clinical Properties of Deer Velvet

http://www.positivehealth.com/article/nutraceuticals/clinical-properties-of-deer-velvet

Key Takeaways

A compilation of several studies showing the efficacy of DAV, as well as testing the composition and active ingredients.


Study: The effects of New Zealand deer antler velvet supplementation on body

composition, strength, and maximal aerobic and anaerobic performance

https://blog.priceplow.com/wp-content/uploads/2013/05/broder-deer-antler-velvet-study.pdf

Key Takeaways

The results of this study suggest that NZDAV may have positive effects on body composition and strength/power in men undergoing resistance training.

 

CBD Research

 

The Biology and Potential Therapeutic Effects of Cannabidiol

https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2015/biology-potential-therapeutic-effects-cannabidiol

Key Takeaways

There is significant preliminary research supporting the potential therapeutic value of CBD with regard to anti-seizure, neuroprotection, anti-inflammatory, analgesic effects, anti-psychotic, and anti-anxiety – and while it is not yet sufficient to support drug approval, it highlights the need for rigorous clinical research in this area.


Cannabidiol (CBD) — What We Know and What We Don’t

https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476

Key Takeaways

We need more research but CBD may be prove to be an option for managing anxiety, insomnia, and chronic pain.


Therapeutic potential of cannabinoid-based drugs.

composition, strength, and maximal aerobic and anaerobic performance

https://www.ncbi.nlm.nih.gov/pubmed/17713029

Key Takeaways

This anti-inflammatory potency has led to the testing of these drugs in chronic inflammatory laboratory paradigms and even in some human diseases. Psychoactive and nonpsychoactive cannabinoid-based drugs such as Delta9-tetrahydrocannabinol, cannabidiol, HU-211, and ajulemic acid have been tested and found moderately effective in clinical trials of multiple sclerosis, traumatic brain injury, arthritis, and neuropathic pain. Furthermore, although clinical trials are not yet reported, preclinical data with cannabinoid-based drugs suggest efficacy in other inflammatory diseases such as inflammatory bowel disease, Alzheimer’s disease, atherosclerosis, and osteoporosis.


Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/21238581

Key Takeaways

This review discusses recent studies suggesting that cannabidiol may have utility in treating a number of human diseases and disorders now known to involve activation of the immune system and associated oxidative stress, as a contributor to their etiology and progression.


Cannabinoids in the management of difficult to treat pain

composition, strength, and maximal aerobic and anaerobic performance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/

Key Takeaways

Numerous randomized clinical trials have demonstrated safety and efficacy in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain.